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its reduction can lead to a higher propensity for clot formation
& Singh, A
With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
These metabolites, elevated at baseline, are hallmarks of incomplete oxidative metabolism and are typically upregulated in contexts of mitochondrial dysfunction and tissuelevel hypoxia 32,58
It is not an inevitable trade-off of the weight loss process
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