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After administration of Triple GLP-1/GIP/glucagon receptor agonist, learning and memory impairment of AD models (APP/PS1 mice and 3Tg-AD mice) was improved, amyloid plaques, tau pathology, inflammation response and oxidative stress in brains of two AD models were ameliorated (239241)

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The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, et al

The DAC modification allows the molecule to circulate for days rather than minutes, producing a sustained elevation often described as a "GH bleed" a continuous, less pulsatile rise