These large studies on SGLT2 inhibitors have largely excluded patients with autoimmune diseases due to concerns for confounding from immunosuppression

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Glucagon receptor agonists Co-agonist and multi-agonist synthetic incretin-based peptides incorporating GCGR agonism are now advancing in pharmaceutical pipelines
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Tirzepatide Tirzepatide is a synthetic peptide that acts as a dual hormone receptor agonist