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From the other PAMPs tested, only furfurman at the highest dosage increased hFAP calcium mineralization, and all other PAMPs tested either had no effect (flagellin, CpG ODN, gardiquimod, M-Tri-DAP and TDB) or were toxic to these cultures (poly (I:C)), (Fig
Adjustments based on measured levels reduce risk and improve outcomes
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The Phase II Trial (NCT01349959) of azacitidine combined with entinostat in TNBC showed limited clinical efficacy, despite considering epigenetic changes (e.g., reduced methylation), indicating that better results could be achieved with higher dosages or combinatorial immunotherapy [241]
