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And a lactam bridge is formed between an aspartate and a lysine side chain, cyclizing the peptide into a ring rather than leaving it linear
Notably, BoNT/X was approximately tenfold more toxic than X(PC) in this cell line, as measured by CellTiter-Glo assay 48 h after transfection (Extended Data Fig
W.KimmelmanA
10.1016/j.cmet.2017.01.014PMID: 28111214
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