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Obesity Reviews: An Official Journal of the International Association for the Study of Obesity, 22 Suppl 4 (Suppl 4), e13261
Semaglutide works by activating only the GLP-1 receptor, while tirzepatide activates both GLP-1 and GIP receptors
These may have mild metabolic effects when taken orally, but there is no scientific evidence that they work through a patch
The medication simply makes the deficit larger and faster than most people would achieve through diet alone, which amplifies the risk if muscle-protective behaviors are not in place
The most successful weight loss outcomes happen when a GLP-1 is paired with a balanced diet and regular physical activity
