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Second, the current studies largely rely on cellular and animal models, whereas human colonic organoids may be more suitable since they are more physiologically relevant and better simulate the epithelial microenvironment

At the early stage of prediabetes, the OGTT results demonstrated that the insulin exhaustion appeared in the second phase of insulin release

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If glucose is consistently above 250 mg/dL, especially with symptoms like nausea, vomiting, abdominal pain, rapid breathing, or fruity breath odor (signs of diabetic ketoacidosis), seek urgent medical care