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However, the associations between GLP-1RAs and bulimia nervosa or PTSD were based solely on evidence from Mendelian randomization analysis
Cons daily dosing, unproven long-term data, likely out-of-pocket cost
While semaglutide is not currently listed as causing allodynia in FDA prescribing information, patients with diabetes may already be at risk for nerve pain from their underlying condition
Monitoring weight weekly and adjusting dose based on trends helps find the minimum effective maintenance dose
The ATTAIN-MAINTAIN Phase 3 trial specifically evaluated this scenario, testing whether patients who had achieved weight loss with injectable GLP-1 receptor agonists (semaglutide or tirzepatide) could switch to oral orforglipron while maintaining their weight loss
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