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It usually appears around 34 years of age in Caucasians and 43 years in individuals of African descent.1 However, it is defined as premature graying (PG) when at least 5 gray hairs appear before the age of 20 years in Europeans, 25 gray hairs in Asians, and before 30 years of age in Africans.2 Hair symbolizes well-being and health and plays an important role in social communication, self-perception, self-esteem, and body Image.3 Recently, the treatment of premature graying has been increasingly studied due to its psychological consequences and its possible association with metabolic diseases.4,5 Hair follicle melanogenesis Hair follicle melanocytes are categorized into subpopulations according to their function, degree of differentiation, and location

Timing also mattersinitiating HRT earlier in menopause may provide greater benefits with fewer risks. The safest approach is a provider-guided plan that balances potential risks with expected benefits and aligns with each womans individual needs