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The current public schedule is: TRIUMPH-1: general obesity, 80-week treatment duration, the largest TRIUMPH trial, pivotal for the NDA filing

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Glutamate and -KG serve as important exchangers in the MAS, and since GLS1 knockdown significantly suppresses NADH and ATP production in cancer cells 143 , the supply of glutamate and -KG for the induction of MAS activity is evidently critical for ATP production in cancer cells (Fig

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