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This overlap is the main reason for staggered titration - start one compound first, build tolerance, then add the second

Documentation and tracking Keep a simple log for each vial: reconstitution date, water volume added, concentration, and a running tally of doses drawn with dates

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Abbreviations A: Amyloid- NPY1R: Neuropeptide Y Y1 receptor VIP: Vasoactive intestinal peptide CRH : Corticotropin-Releasing Hormone ACTH : Adrenocorticotropic Hormone CCK: Cholecystokinin DSIP: Delta Sleep-Inducing Peptide GPCR: G protein-coupled receptors References Aguilera G (1994) Regulation of pituitary ACTH secretion during chronic stress

Duzel, A., Vlainic, J., & Seiwerth, S