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Acknowledgements This work was supported by the National Natural Science Foundation of China (No

Pepin M, Schwarze U, Superti-Furga A, Byers PH

These medications help: Slow down digestion Increase feelings of fullness Reduce appetite Improve body's response to insulin While they were originally developed to treat type 2 diabetes, GLP-1 medications are now widely prescribed for weight management as well

Trump announces major developments in bringing most-favored-nation pricing to American patients, The White House (2025) GLP-1s for weight management, Health Economics and Policy Lab (2025) Weight management medications for chronic use, VA Pharmacy Benefits Management Services and National Formulary Committee (2025) 2025 abbreviated formulary, BlueCross BlueShield Federal Employee Program (2025) 2025 Aetna pharmacy drug guide, Aetna (2025) Cigna Healthcare drug lists for plans offered by employers, Cigna (2025) Things to include in your appeal letter, Patient Advocate Foundation (n.d.) The impact of obesity-related complications on healthcare costs outcomes of a pharmacoeconomic weight loss model, ClinicoEconomics and Outcomes Research (2025) Pharmacotherapy for obesity: recent updates, Clinical Pharmacology (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

Next to the points mentioned above, considering the very limited number of human studies, it will be key to increase clinical research in this area using randomized controlled trials and focusing on collecting prospective longitudinal data, including all appropriate control groups