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One of the physiological substrates of this transporter is acetylcholine, underlying a key role in the non-neuronal cholinergic system in both physiological and pathological conditions, as testified by the occurrence of a natural mutation of OCTN1 in inflammatory conditions such as Crohns Disease (Pochini et al., 2019)

It is important to note that mood state is commonly assessed by self-rating scales, such as self-administered questionnaires, which are not objective measurements (101)

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