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Interleukin-1 (IL-1) receptor antagonist gene polymorphism in normal weight obese syndrome: relationship to body composition and IL-1 alpha and beta plasma levels

In trial 1, the mean change in AHI at week 52 was a reduction of 25.3 events per hour with tirzepatide, compared to a reduction of 5.3 events per hour with placebo, resulting in a treatment difference of -20.0 events per hour (95% CI, 25.8 to 14.2

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Specifically, GLP-1R emerged as an important pharmacological target for addressing T2DM, as it actively contributes to maintaining glucose homeostasis while promoting both cell proliferation and insulin release [35]

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