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Gastrointestinal adverse effects, initially viewed as limiting, were ultimately managed through dose titration and formulation design
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Unlike genomics or proteomics, which survey upstream regulatory layers, metabolomics provides an immediate snapshot of biochemical activity and cellular physiology ( 4.6 Analytical advances revealing metabolic disruptions The rapid evolution of analytical technologies, including mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy, has accelerated metabolomics-based DKD research (Zhang et al., 2025c)