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The drugs also replicate the effects of the GLP-1 hormone, which is a part of the reward pathways in the brain that drive people to participate in pleasurable activities like eating food
When approaching the isoelectric point (IEP) of the protein at about pH 4.5 (and below), the resulting CGN-protein structure with increased crosslinkages is so strong that the complex will precipitate
However, it suggests that in real-world settings with appropriate lifestyle support, the difference between the medications may be smaller than trial data indicate
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