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This disconnection between expectation and reality may have significant detrimental effects on self-esteem, confidence, and quality of life
While the facilities that produce them are regulated by the FDA, the compounded drugs themselves have not been evaluated by the agency for safety, efficacy, or quality
From the anesthesiologist point of view, the growing number of patients treated with incretin-based therapies undergoing deep sedation and general anesthesia uncover the possible dark side of these drugs such as revealed by many case reports documenting the association between general anesthesia and gastric aspiration of a large amount of gastric content (including undigested food particles) in patients taking GLP1-RAs during the peri-operative period [10,11,12]
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Nausea, vomiting, or constipation in weeks 24 can reduce food intake due to discomfort rather than semaglutide's intended appetite-suppression effect, and may prompt dose reductions that delay reaching therapeutic levels
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