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In a co-administered protocol the three components depopulate at different rates from a single bolus, which is one of the legitimate criticisms of any fixed-ratio blend: the researcher cannot independently titrate frequency for the shorter-half-life components without also re-dosing the longer-half-life one

Inadequately performed treatments can trigger rebound pigmentation, burns, or uneven tone, often costing significantly more to correct than investing in the right treatment initially

Epigallocatechin-3-gallate (EGCG) suppresses the trafficking of lymphocytes to epidermal melanocytes via inhibition of JAK2: its implication for vitiligo treatment

it may also increase risk of certain eye diseases