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In this case, supporting small and sustainable changes to lifestyle can still yield important improvements, but additional therapeutics are often still necessary to address the detrimental chronic presence of NAFLD

5.1 EPO EPO is a classic regulator of erythropoiesis, but it also exhibits direct anti-eryptotic effects

PDE1B inhibition primarily enhances D1 receptor-mediated signaling, improving cognitive and negative symptoms, whereas PDE10A inhibition targets D2 receptor-mediated hyperactivity to alleviate positive symptoms

If this trajectory holds in phase 3, amycretin could achieve greater long-term weight loss