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Serious adverse effects are uncommon but possible, including allergic reactions, severe injection site reactions if improper technique is used, and excessive detoxification responses in susceptible individuals
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J Transl Med 15 , 232 (2017)
This design increases its half-life from minutes to several hours, allowing for greater receptor activation in tissues such as muscle and tendon
An increased activation of IDO and its subsequent enzyme kynurenine monooxygenase by proinflammatory cytokines, moreover, leads to an enhanced production of quinolinic acid, a strong agonist of the glutamatergic N -methyl-D-aspartate receptor
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