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They serve different roles in healthcare
The problem is the majority of GLP-1-producing L cells are located at the lower part of our digestive tract, way at the end of our small intestine, known as the distal ileum, and especially in our colon
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A heart that beats faster AND harder delivers more oxygen to working muscles
It is an imbalanced agonist with GIPR potency close to native GIP but weaker GLP-1R affinity, and shows biased GLP-1R signaling, favoring cAMP over -arrestin recruitment
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