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In an unbound state, the AR complexes with heat-shock, chaperone and co-chaperone proteins (such as HSP90, HSP70, and p23), which helps to maintain the apo state of the AR in a state competent to bind ligand (Figure 1A) 73
doi: 10.3389/adar.2023.10901 Received 13 September 2022 Accepted 09 January 2023 Published 18 January 2023 Volume 3 - 2023 Edited by Emmanuel Onaivi, William Paterson University, United States Reviewed by Qing-Rong Liu, National Institute on Aging (NIH), United States Syed Ali, National Center for Toxicological Research (FDA), United States Updates Copyright 2023 Virmani
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