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MTR (methionine synthase) the enzyme that uses 5-MTHF to regenerate methionine from homocysteine requires cobalamin (B12) as its essential cofactor
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Mechanism & Research Background MOTS-C is a 16-amino-acid peptide with the sequence MRWQEMGYIFYPRKLR, encoded by the MT-RNR1 gene within the 12S rRNA region of mitochondrial DNA
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5-Amino-1MQ targets it through NNMT inhibition
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