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It mimics the hormone produced in the gastric system after eating, and, in higher doses, interacts with the brain to suppress appetite
For patients not on an antihyperglycemic agent at study entry, mean reductions from baseline in A1C were: Januvia 100 mg once daily, -1.1%
Furthermore, tirzepatide is not classified as a controlled substance by the Drug Enforcement Administration (DEA)
Mechanistically, this is accomplished by activating key metabolic regulators
Example: Someone stable on levothyroxine for years, TSH around 2, starts an over-the-counter supplement with L-carnitine and notices increasing tiredness and a later TSH of 5
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