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This redox imbalance promotes mitochondrial DNA damage, lipid peroxidation, and activation of apoptotic pathways, ultimately contributing to myofibrillar disorganisation and interstitial fibrosis (73)
10.1042/bj3260305 43 JonesA
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(2014) Meta-analysis of methylcobalamin alone and in combination with prostaglandin E1 in the treatment of diabetic peripheral neuropathy
Enhanced extracellular matrix deposition has also been observed, indicating regulated synthesis and assembly of key structural proteins such as collagen and elastin, which are essential for restoring tissue strength and elasticity in experimental systems
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