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JACC Basic Transl Sci 4:575591 Tochiya M, Makino H, Tamanaha T, Matsuo M, Hishida A, Koezuka R, Ohata Y, Tomita T, Son C, Miyamoto Y, Yasuda S, Hosoda K (2020) Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type 2 diabetes and heart diseases: A pilot study

doi: 10.1056/NEJMoa1607141 18 HolmanRRBethelMAMentzRJThompsonVPLokhnyginaYBuseJBet al

It describes the protocol as a lower amount with a slower advancement pace, best suited to people new to this drug class, those with mild to moderate metabolic goals, and anyone wanting to test their own tolerance before committing further

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These results underscore the importance of personalized care strategies and proactive follow-up to ensure patients remain on therapy when appropriateor transition off it safely when needed