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BAL fluid and intracellular GSH pathways correlate with HAEC T2-associated gene expression To determine whether these in vitro findings were reflected ex vivo, BAL fluid GSSG levels were compared to fresh HAEC expression of T2-related genes from 2 different RNA-Seq databases (SARP3 and IMSA), which were harmonized and merged as outlined in the Methods (Table 3)
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For those new to semaglutide, it is a GLP-1 receptor agonist that mimics natural hormones in the body to regulate blood sugar, slow digestion, and reduce appetite
Patients should be counseled to: Consume smaller, more frequent meals (56 per day) rather than large portions Emphasize low-fat, low-fiber foods that empty more readily from the stomach Ensure adequate hydration, particularly with liquid calories if solid food tolerance is poor Avoid lying down immediately after meals Chew food thoroughly and eat slowly For patients developing concerning symptoms, temporary dose reduction or treatment interruption may be necessary
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