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Lancet 2021 Phase 2 (monotherapy) Lau et al., n=706, 26 weeks

Sikiric, P., Seiwerth, S., Grabarevic, Z., et al

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However, the administration of either treatment supplement did not yield any significant effects on skin elasticity or hydration

These findings support the hypothesis that individuals with T21 experience impaired detoxification and antioxidant buffering, which can be partially restored through integrated nutritional interventions