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This binding activates the receptors and triggers physiological responses that help control blood sugar levels

CagriSema, under investigation for people with obesity as well as type 2 diabetes, has also shown weight loss (up to 15.6% reduction) as well as improved A1C (up to 2.18% reduction) in its phase 2 clinical trial

Petersen J, Ludwig MQ, Juozaityte V, Ranea-Robles P, Svendsen C, Hwang E et al (2024) GLP-1-directed NMDA receptor antagonism for obesity treatment

rs1169299 and rs10466245 were also related to diabetes in DIAGRAM and HDL-cholesterol in GLGC respectively but did not reach genome-wide significance