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If middle-aged women were to start a revolution, their leader might be Dr
Examples of patients with extreme plasma TMAO levels include those with cobalamin synthesis disorders, cystinosis (OMIM219800), isovaleric acidemia (OMIM243500), and maple syrup urine disease (OMIM248600) (Fig
By integrating molecular structural optimization, advanced permeability assays like BBB-PAMPA , and real-time neuropharmacokinetic tools such as brain microdialysis , the pharmaceutical industry is making incremental progress towards transformative therapies for AD, PD, and other CNS disorders
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In the short-term, however, the paper emphasizes the importance of nailing down just how metabolites within different compartments operate within our cells
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