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But, it can also affect how the body absorbs nutrients, like vitamin B12

A recent analysis of the USFDA Adverse Event Reporting System revealed that patients taking both metformin and a PPI experienced significantly higher rates of hospitalizations and life-threatening complications related to B12 deficiency (such as severe neuropathy and cognitive decline) compared to those on monotherapy

Temperature mishandling Adding cold water to cold powder slows dissolution and may not fully hydrate the lyophilized structure

That finding is significant

Additionally, the injection method allows for maximum absorption, making it a great option for those who may have difficulty absorbing B12 through food or oral supplements