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A practical severity estimate based on the available preclinical signals: Serotonergic risk : Low-to-moderate plausibility based on rodent monoamine modulation data, but direction of effect (agonism vs
Step 5: Hold for the full duration This is the most critical step
Of these, ~1,950 people are to be enrolled in STEP 1 trial, which aims to induce weight loss over a period of 68 weeks
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