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Reduction figures are averages from published clinical trials of the medications' active ingredients: semaglutide (Wilding et al., New England Journal of Medicine , 2021

The effects of glutathione whitening are long-lasting, provided that the supplementation is continued

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N-acetyl-L-cysteine (NAC), a well-characterized thiol antioxidant and precursor of reduced glutathione (GSH), not only scavenges intracellular ROS directly but also replenishes depleted GSH stores in erythrocytes, thereby inhibiting ROS-mediated Ca 2+ influx and PS externalization induced by eryptosis triggers such as desipramine or uremic toxins