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In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)

Vegetarians and vegans who eat minimal animal products, which are rich in B12

For athletes, maintaining optimal B12 levels can mean the difference between a great workout and hitting a wall

Reference: Nicotinamide N-Methyltransferase in Cardiovascular Diseases: Metabolic Regulator and Emerging Therapeutic Target (2025)

The effects typically last for several days to weeks, depending on individual needs and lifestyle