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Key takeaways IGF-1 LR3 is a synthetic peptide with 13 extra amino acids that stays active longer in the body than natural IGF-1
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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before
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