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Any successful weight loss, whether its diet, bariatric surgery, or GLP-1s, will cause a decrease in lean body mass, says Dr

Across clinical trials and real-world settings, weight loss remained modest, relapse rates after discontinuation were high, and treatment was often fragmented, lacking integration into interdisciplinary care models

Suggestive as these changes clearly are, they likely represent only a small minority of the full breadth of pathogenically relevant changes in this dataset, many of which may involve proteins with as-yet poorly explored functions