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Safety Profile: What We Learned About Side Effects Common Adverse Events The TRIUMPH-4 trial confirmed that retatrutide's side effect profile aligns with other incretin-based therapies, with gastrointestinal symptoms being the most common: Incidence of GI Side Effects (12mg dose): Nausea: 43% (vs 11% placebo) Diarrhea: 33% (vs 13% placebo) Vomiting: 21% (vs 0% placebo) Constipation: Elevated vs placebo Decreased appetite: Common Most gastrointestinal side effects were mild to moderate in severity and occurred primarily during the dose escalation phase
Swelling or pain in the legs, chest pain or shortness of breath may indicate clotting issues and should be reported immediately
Low Side Effect Profile: Demonstrates minimal interaction with non-target endocrine pathways in laboratory settings
People with certain medical conditions, like pancreatitis or a history of thyroid cancer, may not be able to use this medication
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