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First-line approaches recommended by NICE and the NHS include: Dietary modification a balanced, calorie-reduced diet tailored to individual needs, with guidance from a registered dietitian where appropriate Increased physical activity at least 150 minutes of moderate-intensity aerobic activity per week for adults, in line with the UK Chief Medical Officers' physical activity guidelines Behavioural interventions cognitive behavioural therapy (CBT)-based programmes, group support, and self-monitoring strategies For individuals with a BMI of 30 kg/m or above (or 27.5 kg/m in certain ethnic groups), pharmacological treatment may be considered alongside lifestyle interventions, subject to clinical assessment and specific eligibility criteria: Orlistat reduces dietary fat absorption and is available via GP prescription
Labs are included if needed and your provider will go over the results with you to identify any health gaps
The fundamental mechanism of action involves mimicking the physiological effects of endogenous GLP-1, which is secreted by intestinal L-cells in response to food intake
doi: 10.1186/1471-2202-13-33 145 GaberySSalinasCGPaulsenSJAhnfelt-RnneJAlanentaloTBaqueroAFet al
They reported losing 35 pounds overall but struggled with side effects at higher doses, including food aversion and an extremely sensitive gag reflex
