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Appetite changes: The reduction in hunger that eventually produces weight loss begins during this period
Clinical trials show that while some weight loss persists after discontinuation, most people regain 5070% of lost weight within one year without ongoing medication or significant lifestyle reinforcement
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Current 2024 multi-society guidance from the American Society of Anesthesiologists emphasizes individualized risk assessment rather than routine discontinuation
Testing before and during therapy helps refine dosage and timing
