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whereas M2 is induced by IL-4 and IL-13 and secretes anti-inflammatory IL-10, IL-1 decoy receptor, and arginase which further blocks the IL-1 and iNOS activity
PPP activity is minimal in muscle and the brain, where almost all of the glucose is used glycolysis for energy, ATP production
Important safety considerations include a boxed warning for medullary thyroid carcinoma (MTC) risk with most GLP-1 medications, which are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
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Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*
