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These cation-selective ligand-gated ion channels are activated by the excitatory neurotransmitter glutamate and mediate fast excitatory synaptic transmission in mammalian brains 1,2

Navolanic PM, Steelman LS, Leslie NR, Coffer PJ, Konopleva M, Hu W, Andreeff M , Blagosklonny MV, McMahon M, McCubrey JA

The UPR has three canonical branches (PERK/ATF4, IRE1a/XBP1, and ATF6), which play a central role in mitigating cellular stress by enhancing protein folding capacity and secretion, activating the oxidative stress response, and inducing autophagy, thereby restoring protein homeostasis (137)

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