Injectable liraglutide (Saxenda, Victoza) Unlike the other injectable GLP-1s on this list, liraglutide must be injected once a day
It also inhibits the breakdown of cartilage, a flexible tissue that protects the ends of your bones in joints ( A study in 100 people over the age of 50 found that treatment with a supplement containing 1,200 mg of MSM for 12 weeks decreased pain, stiffness and swelling in the joints, compared to a placebo ( The group receiving the supplement also reported improved overall quality of life and less difficulty walking and getting out of bed ( Another study in 32 people with lower back pain found that taking a glucosamine supplement containing MSM significantly reduced lumbar stiffness and pain upon movement, plus greatly increased quality of life ( Summary Studies have shown that MSM is effective in reducing joint pain, stiffness and swelling

Those with type 1 diabetes should not be prescribed semaglutide injections, along with anyone who is at a higher risk or has a family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 due to any further increase of risk that could be caused by the injections
Han Z, Ma Y, Wang M (2025) Ferritin protein nanocages for selective separation and recovery of critical metals
Semaglutide is the active ingredient in the brand-name drugs Ozempic , Wegovy , and Rybelsus