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Inhibition of SREBP2-mediated cholesterol synthesis suppresses both the PI3K/AKT and STAT3 pathways, inducing apoptosis and cell cycle arrest in HCC cells [236]

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Aside from SCFAs, a recent body of research emphasizes the significance of tryptophan-derived indoles, which influence neuroimmune balance via AhR activation, resulting in tighter BBB control and less peripheral-to-central inflammatory communication [145]

Starting at a low dose and increasing slowly helps