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The forward-looking statements contained in this communication are made only as of March 18, 2026

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Furthermore, glutamine-derived fumarate, malate, and citrate are significantly increased when glucose is deprived, demonstrating that glutamine drives the glucose-independent TCA cycle in a nutrient-poor tumor microenvironment (Le et al., 2012)

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All GLP-1 receptor agonist drugs, like semaglutide, slow down gastric emptying and reduce stomach acid production

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