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However, a recent study suggested that upregulated IL-11 drives APAP-induced hepatocyte death, and specific deleting IL-11RA1 in hepatocytes or IL-11 knockdown in mice protected against AILI [215]

In particular, miR-122-5p, which is already established as a critical hepatic biomarker, was upregulated in MASLD serum, consistent with studies in adults