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However, CCL5, as a downstream effector molecule of GZMK, interacts with it and activates the ERK signaling pathway, thereby driving the proliferation, migration, and invasion of synovial fibroblasts, and inhibiting their apoptosis and ferroptosis, ultimately accelerating the progression of experimental rheumatoid arthritis (98)
A.BuenoN
Glycine alleviated diquat-induced hepatic injury via inhibiting ferroptosis in weaned piglets
Collectively, these results highlight the ability of highly engineered apocynin derivatives to specifically inhibit the NOX2 isoform at its mitochondrial source, while substances such as GKT137831 support the more general NOX inhibition strategy to reduce vascular and tissue-specific ROS in fibrotic diseases and diabetic nephropathy
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