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Serious side effects seek medical attention if you experience any of the following: Pancreatitis severe abdominal pain, possibly radiating to your back, with or without vomiting

[1] [4] No, semaglutide is a synthetic medication that mimics natural GLP-1 but with structural modifications that extend its half-life from 1-2 minutes to approximately 7 days

The studies described here examined the acute effect of linagliptin in improving glucose tolerance in chow-fed mice and found that pancreatic GLP-1 is an important source for the inhibitory effects of DPP-4

And thats normal

Know What to Do If You Miss a Dose Life happens, and even with the best intentions, you might miss a dose of your medication