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29 GLP-1, an endocrine hormone, is secreted by enteroendocrine L-cells located in the distal jejunum, ileum, and colon in response to nutrient ingestion and neuroendocrine stimulation

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Second, niacinamide is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme central to cellular energy metabolism, mitochondrial function, and DNA repair