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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in vegans or vegetarians without malabsorption issues Patient preference where absorption is intact Maintenance therapy in some cases following initial injection therapy Typical oral doses range from 502000 micrograms daily

Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure

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American Academy of Pediatrics Committee on Fetus and Newborn

Compare mechanisms, Phase 2 outcomes, and research applications