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However, the relatively modest increase in ATP production (~22%) compared to the doubling of proton leak suggests that part of the respiratory activity may be uncoupled from ATP synthesis at the end of the study

The post connects this partly to the fasting requirement, which it says may itself reduce tolerability

From geroscience to precision geromedicine: understanding and managing aging

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Prolonged early exposure to a high-fat diet augments the adverse effects on neurobehavior and hippocampal neuroplasticity involvement of microglial insulin signaling